Cleaning and asthma characteristics in women

Source: Orianne Dumas, Valérie Siroux, Frédéric Luu, Rachel Nadif, Jan-Paul Zock, Francine Kauffmann and Nicole Le Moual, American Journal of Industrial Medicine, Vol. 57 Issue 3, March 2014
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From the abstract:
• Background – We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects.
• Methods – Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
• Results – Occupational exposures were associated with more symptomatic asthma and severe asthma. An association was suggested for poorly controlled asthma. Associations were observed for asthma without positive skin prick test, with a low IgE level, and with a low eosinophil count.
• Conclusions – Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.