Targeted versus Universal Decolonization to Prevent ICU Infection

Source: Susan S. Huang, Edward Septimus, Ken Kleinman, Julia Moody, Jason Hickok, Taliser R. Avery, Julie Lankiewicz, Adrijana Gombosev, Leah Terpstra, Fallon Hartford, Mary K. Hayden, John A. Jernigan, Robert A. Weinstein, Victoria J. Fraser, Katherine Haffenreffer, Eric Cui, Rebecca E. Kaganov, Karen Lolans, Jonathan B. Perlin, and Richard Platt, New England Journal of Medicine, Vol. 368 No. 24, June 13, 2013

From the abstract:
Both targeted decolonization and universal decolonization of patients in intensive care units (ICUs) are candidate strategies to prevent health care–associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA)….In routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen.
See also:
MRSA Study Results, MRSA Study Slashes Deadly Infections in Sickest Hospital Patients
Source: Agency for Healthcare Research and Quality, Press Release, May 29, 2013